Hi - I have the same problem. Syncmate cannot detect a USB connection. But it worked fine for Missing Sync while I was using that - also when I go to Network in preferences, it shows my Motorola Q (Windows Mobile 5) connected. But Syncmate doesn't seem to see it.
When I plug the Q Phone in, the "Connecting" grey window appears for a few seconds then disappears. And that's it. SyncMate doesn't show a connection.